Highlights
Rring-opening polymerization for constructing multicyclic polymers
Cyclic polymers have a number of unique physical properties compared with those of their linear counterparts. However, the methods for the synthesis of cyclic polymers are very limited, and some multicyclic polymers are still not accessible now. We found that the five˗membered cyclic structure and electron withdrawing groups make methylene in rhodanine highly active to aldehyde via highly efficient Knoevenagel reaction
The synthesis of polymers with on-demand sequence structures is very important not only for academic researchers but also for industry.. We report a dually switchable and controlled interconvertible polymerization system; in this system, two distinct orthogonal polymerizations can be selectively switched ON/OFF independent of each other and they can be interconverted promptly and quantitatively according to external stimuli.
Synthesis of polymers with on-demand sequence structures via dually switchable and interconvertible polymerizations
High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core
During the last two decades, cationic polymers have become one of the most promising synthetic vectors for gene transfection. However, the weak interactions formed between DNA and cationic polymers result in low transfection efficacy. Furthermore, the polyplexes formed between cationic polymers and DNA generally exhibit poor stability and toxicity because of the large excess of cationic polymer typically required for complete DNA condensation.We report the preparation of a novel class of bioreducible cationic nanomicelles by the use of disulfide bonds to connect the cationic shell to the fluorocarbon core.
News
2024.08.01:Academic Report of Chaozhao Liang of Anhui Medical University
2024.09.27:Academic Report of Hui Xu of Heilongjiang University
2024.11.08:Academic Report of Zunfeng Liu of Nankai University
2024.11.25:Academic Report of Zhikun Zheng of Sun Yat-sen University
2024.11.15:Academic Report of Zesheng An of Jilin University

In situ autophagosome vaccine
Autophagosome-cancer vaccines can promote cross-presentation of multiple tumour antigens and induce cross-reactive T cell responses. We report a functional Ti2NX nanodot that caps the autophagosome membrane lipid phosphatidylinositol-4-phosphate, blocking the fusion of autophagosomes with lysosomes and producing stable nanodot-coated autophagosomes in tumours.
Nature Communication
Nature Communication
Nature Nanotechechnology
Angewandte Chemie
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